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  • Snapshot
    • A 4-year-old boy is brought to the urgent care clinic after falling during school recess. He scraped his right knee on the gravel resulting in a wound. He has no medical issues and his vaccinations are up to date. On exam, he is crying from the pain. After cleaning the wound, an ointment is applied to prevent a bacterial infection.
  • Introduction
    • Drugs
      • bacitracin
        • topical
        • intramuscular injection in pediatrics (rarely used)
        • parenteral therapy is not used as it may cause renal failure
    • Mechanism of action
      • a glycopeptide that interferes with peptidoglycan synthesis, disrupting the cell wall
    • Clinical use
      • primarily staphylococcal and group A streptococcal infections
      • superficial bacterial infections
      • pneumonia or empyema
        • limited use for pediatric patients who failed to respond to less-toxic antibiotics
    • Adverse effects
      • nephrotoxicity
      • contact dermatitis
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