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Updated: Feb 26 2019


  • Snapshot
    • A 60-year-old man presents to the emergency room for a swollen, red hand. He reports sustaining a fall 2 days ago onto the affected hand. Since then, he has had fevers, chills, and increased redness spreading from the site of trauma. He has a past medical history of recurrent MRSA infections, intravenous drug use, and diabetes mellitus. A search into his medical record shows that he has been treated for vancomycin-resistant MRSA in the past year. A newer generation tetracycline derivative has been used successfully in the past to treat his soft tissue infections. He is empirically started on this drug after blood cultures are drawn. (Cellulitis)
  • Introduction
    • Drugs
      • tigecycline
        • a glycylcycline, a tetracycline derivative
        • intravenous (IV) only
    • Mechanism of action
      • binds to bacterial ribosomal 30S subunit, which inhibits protein synthesis
      • bacteriostatic
      • mainly eliminated via stools
    • Clinical use
      • broad-spectrum antibiotic with activity against gram-negative, anaerobic, and gram-positive organisms
        • MRSA
        • VRE
      • skin and soft-tissue infections
      • intra-abdominal infections
      • no activity against Pseudomonas
    • Adverse effects
      • gastrointestinal upset
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