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Updated: Feb 26 2019


  • Snapshot
    • A 25-year-old woman presents to the urgent care clinic for vaginal itching and discharge. She recently completed a course of antibiotics for the treatment of urinary tract infection. On physical exam, there is white discharge with erythema and swelling of the vulva. She requests a topical agent, as she did not want to take any medications by mouth. She is instructed to use a topical cream. (Vaginal candidiasis)
  • Introduction
    • Drugs
      • nystatin
        • topical use only
        • side effects are too toxic to be given systemically
    • Mechanism of action
      • binds to ergosterol, a key component of the cell membrane, which forms pores that allow for leakage of cellular contents
    • Clinical use
      • candidiasis
        • cutaneous (intertrigo and diaper rash)
        • mucocutaneous (oral thrush and vaginal candidiasis)
    • Adverse effects
      • skin irritation or hypersensitivity
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