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Updated: Oct 20 2015

Introduction to Chlamydia and Rickettsia

  • Overview
    • Chlamydia and Rickettsia are 2 groups of Gram-negative bacteria
    • Both bacteria are
      • obligate intracellular parasites
        • they must steal host ATP to live
          • Chlamydia cannot make any ATP whatsoever
          • Rickettsia can make some (but not enough)
        • they cannot be cultured on non-living artificial media
          • instead, they are innoculated into living cells for culture
      • about the size of large viruses (i.e. quite small)
        • however, they are not viruses because they
          • have both DNA and RNA
            • viruses have only one or the other
          • synthesize their own proteins
          • are sensitive to antibiotics
    • Important differences between the 2 groups include
      • Differences between Chlamydia and Rickettsia
      • Chlamydia
      • Rickettsia
      • Transmission
      • Person-to-person
      • Arthropod vector
      • Site of replication
      • Endosomes
      • Cytoplasm
      • Type of cell attacked
      • Columnar epithelium
      • Endothelium
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