Please confirm topic selection

Are you sure you want to trigger topic in your Anconeus AI algorithm?

Please confirm action

You are done for today with this topic.

Would you like to start learning session with this topic items scheduled for future?

Updated: Feb 27 2019


  • Snapshot
    • An 82-year-old woman is brought to the emergency room for fevers and altered mental status. She becomes combative and was put in restraints. Her temperature is 102°F (38.9°C) and her blood pressure is 103/74 mmHg. Physical exam shows suprapubic tenderness. Blood and urine cultures are drawn, and urinalysis reveals the presence of leukocyte esterase. Upon further investigation, past medical records show that she has previously been treated for vancomycin-resistant enterococci (VRE). She is started on linezolid. (Urinary tract infection)
  • Introduction
    • Drugs
      • linezolid
        • an oxazolidinone drug
    • Mechanism of action
      • binds to the 23S ribosomal RNA of the 50S subunit and inhibits protein synthesis
        • prevents initiation complex formation with 70S subunit
      • bacteriostatic against enterococci and staphylococci
      • bactericidal against most streptococci
    • Mechanism of resistance
      • mutation of ribosomal RNA to prevent binding
    • Clinical use
      • gram-positive organisms
        • used especially for multi-drug resistant organisms like methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE)
      • community-acquired pneumonia
      • skin and soft tissue infections
      • urinary tract infection
    • Adverse effects
      • myelosuppression
      • peripheral neuropathy
      • serotonin syndrome
        • due to the drug’s weak reversible action as a monoamine oxidase inhibitor (MAOI)
        • treat with benzodiazepines or cyproheptadine
      • contraindicated while using MAOIs (phenelzine or isocarboxazid)
      • gastrointestinal upset
        • C. difficile diarrhea
1 of 0
Private Note

Attach Treatment Poll
Treatment poll is required to gain more useful feedback from members.
Please enter Question Text
Please enter at least 2 unique options
Please enter at least 2 unique options
Please enter at least 2 unique options