Snapshot A 15-year-old boy presents with 1 week of fever and sore throat. A few days ago, the patient had gone to an urgent care and had started taking amoxicillin for a presumed bacterial infection. On the 2nd day of antibiotics, he developed a rash. He works at a daycare center after school every weekday. On physical exam, he is found with a diffuse maculopapular rash as well as cervical lymphadenopathy and tonsillar exudates. A Monospot test was positive. He was counseled to stop the antibiotics and to avoid contact sports during this illness. Introduction Classification login to view 5 more bullets Epidemiology login to view 14 more bullets Pathogenesis login to view 4 more bullets Associated conditions login to view 6 more bullets Prognosis login to view 1 more bullet Presentation Symptoms login to view 4 more bullets Physical exam login to view 5 more bullets Studies Labs login to view 4 more bullets Making the diagnosis login to view 1 more bullet Differential Cytomegalovirus login to view 3 more bullets Treatment Management approach login to view 1 more bullet Conservative login to view 6 more bullets Complications Splenic rupture Malignancy Hemolytic anemia login to view 1 more bullet Guillain-Barre syndrome