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Topic
Snapshot
  • A 3-month old girl is brought to the emergency room with difficulty breathing. She was a preterm baby, born at 36 weeks, and has been tracking along the 50% percentile for height and weight. There were no other complications associated with her birth or development. She is up to date on all vaccines. On physical exam, there is audible wheezing, coughing, and rhinorrhea, suspicious for an RSV infection. She is given an antiviral medication. (Bronchiolitis)
Introduction
  • Drugs
    • ribavirin
  • Mechanism of action
    • inhibits inosine monophosphate dehydrogenase which disrupts the synthesis of guanine nucleotides
  • Clinical use
    • chronic hepatitis C
      • used with other anti-hepatitis C agents
    • respiratory syncytial virus (RSV) infections
      • marginal benefit in those with severe disease 
  • Adverse effects
    • hemolytic anemia
    • myocardial infarction
    • teratogenic
      • avoid in pregnancy
      • effects may persist up to 6 months after completion of medication
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Questions (1)

(M1.MC.13.90) A 4-month-old male presents to the emergency department with severe cough, wheezing, and cyanosis. You suspect bronchiolitis of viral etiology and you administer an anti-viral medication. This drug is often used to treat which one of these other infections? Tested Concept

QID: 100893
1

HIV

4%

(18/425)

2

Hepatitis B

11%

(45/425)

3

Hepatitis C

32%

(136/425)

4

Rhinovirus

28%

(120/425)

5

HSV

22%

(92/425)

M 3 E

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Evidence (3)
Topic COMMENTS (2)
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