Topic
Review Topic
0
0
Snapshot
  • A 56-year-old man with a history of HIV presents to the emergency room with fevers, headaches, and general malaise. A head CT shows soap bubble lesions and variable enhancing lesions, concerning for Cryptococcus. A lumbar puncture and subsequent India ink stain on cerebral spinal fluid show yeast with clear halos, confirming the diagnosis. He is admitted immediately and started on dual anti-fungal therapy. (Cryptococcal meningitis)
Introduction
  • Drugs
    • flucytosine
  • Mechanism of action
    • the drug is converted to 5-fluorouracil and inhibits nucleic acid synthesis
    • cleared renally
  • Clinical use
    • Cryptococcal infections
      • used with amphotericin B
    • systemic fungal infections
      • candidal infections resistant to azoles
  • Adverse effects
    • bone marrow suppression
    • gastrointestinal upset
    • hallucinations
    • renal failure
      • use with caution in those with renal failure
 

Please rate topic.

Average 5.0 of 2 Ratings

Thank you for rating! Please vote below and help us build the most advanced adaptive learning platform in medicine

The complexity of this topic is appropriate for?
How important is this topic for board examinations?
How important is this topic for clinical practice?
Topic COMMENTS (0)
Private Note