0%
Topic
Review Topic
0
0
N/A
N/A
Questions
2
0
0
0%
0%
Evidence
2
0
0
Topic
Snapshot
  • A 28-year-old woman presents to her primary care physician due to dysuria. Her symptoms began approximately 2-3 days ago and have progressively worsened. She has a past medical history of mild asthma. She is allergic to penicillin, which causes her to have a severe skin rash and shortness of breath. Her symptoms are associated with urinary urgency and frequency. Physical examination demonstrated tenderness to palpation of the suprapubic region. A urinalysis and urine culture are ordered, which demonstrates Proteus mirabilis infection. She is treated with aztreonam.
Introduction
  • Mechanism of action
    • a monobactam that binds to penicillin-binding proteins 3 (PBP-3), which inhibits transpeptidation
      • impairs peptidoglycan synthesis, a needed component of cell wall biosynthesis
      • no cross-allergy with penicillins
  • Mechanism of resistance
    • altered PBP-3
  • Clinical use
    • gram-negative rods only  
      • especially in patients who are allergic to penicillins or intolerable to aminoglycosides
  • Adverse effects
    • gastrointestinal upset (occasional)

Please rate topic.

Average 5.0 of 2 Ratings

Questions (2)
Question locked
Sorry, this question is for
PEAK Premium Subscribers only
Upgrade to PEAK
Question locked
Sorry, this question is for
PEAK Premium Subscribers only
Upgrade to PEAK
Evidence (2)
EXPERT COMMENTS (2)
Private Note