Updated: 1/13/2019

Anti-Pseudomonal Penicillins

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Introduction
  • Classification
    • antibiotic
      • penicillin-family (β-lactam)
        • penicillin
          • antipseudomonal penicillins
  • Drugs
    • carbenicillin (oral)
    • ticarcillin (IV)
    • piperacillin (IV)
Mechanism
  • Action
    • see Penicillin 
  • Resistance
    • penicillinase sensitive
      • most S. aureus are resistant
Uses
  • Many Gram-positive, Gram-negative, and anaerobic bacteria
  • Pseudomonas spp.
  • Anaerobes
    • e.g. Bacteroides fragilis
  • Gram-negative rods
  • Combine with other drugs to improve efficacy
    • used with clavulanic acid, tazobactam, sulbactam (penicillinase inhibitors)
Adverse effects
  • Allergy
 

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