Introduction Clinical signs of ToRCHES infection in the newborn Infections that cross the placenta ("ToRCHeS") Toxoplasma gondii Rubella Cytomegalovirus (CMV) HIV Herpes simplex virus (HSV) HSV-2 is more common, although HSV-1 is also possible Syphilis Signs in the fetus in ToRCHeS infections (nonspecific, common to multiple infections) hepatosplenomegaly fever poor feeding growth retardation jaundice thrombocytopenia hearing impairment mental retardation autism death Other infections that cross the placenta These infections can also cross the placenta coxsackie B virus poliovirus parvovirus B19 Zika virus Listeria monocytogenes