Snapshot A 45-year-old man with a history of HIV infection presents to his primary care doctor for a rash. He had been on antiretroviral medications for his HIV infection for years. Six months ago, he lost his job and his insurance and ran out of medication 5 months ago. He had been feeling fine until a week ago when he developed a painless rash on his face, trunk, and legs. He has also had some night sweats and low-grade fevers. On physical exam, he has multiple scattered reddish purple macules and papules. There are also purple nodules on his oral mucosa. A skin biopsy reveals neoplastic spindle-shaped cells and a lymphocytic infiltrate. Introduction Classification login to view 3 more bullets Epidemiology login to view 11 more bullets Pathogenesis login to view 1 more bullet Associated conditions login to view 2 more bullets Prevention login to view 2 more bullets Prognosis login to view 2 more bullets Presentation Symptoms login to view 3 more bullets Physical exam login to view 6 more bullets Studies Labs login to view 1 more bullet Skin biopsy login to view 2 more bullets Making the diagnosis login to view 1 more bullet Differential Bacillary angiomatosis login to view 3 more bullets Treatment Management approach login to view 2 more bullets Medical login to view 9 more bullets Complications Metastatic progression of disease