Snapshot A 12-year-old boy is brought to the emergency room for cough, high fever, and rash. He also reports having itchy eyes for the past day. The rash started on his head and neck and traveled downward towards his trunk. His vaccination history is unknown. On physical exam, he has a confluent maculopapular rash that is blanching with pressure. There are blue-white macules overlying a background of erythema on the buccal mucosa. He is immediately isolated and admitted to the hospital for supportive care and vitamin A supplementation. Introduction Classification login to view 5 more bullets Epidemiology login to view 8 more bullets Pathogenesis login to view 5 more bullets Prevention login to view 2 more bullets Prognosis login to view 1 more bullet Presentation Symptoms login to view 6 more bullets Physical exam login to view 7 more bullets Studies Labs login to view 2 more bullets Biopsy of lymph node login to view 1 more bullet Making the diagnosis login to view 1 more bullet Differential Parvovirus B19 infection login to view 3 more bullets Treatment Management approach login to view 1 more bullet Conservative login to view 7 more bullets Medical login to view 3 more bullets Complications Subacute sclerosing panencephalitis in adulthood login to view 1 more bullet Encephalitis Giant cell pneumonia login to view 1 more bullet