Snapshot A 22-year-old man presents to his primary care physician for a sore throat and oral lesions. He said his symptoms began a few days ago and have progressively worsened. Initially, his symptoms were associated with fever and submandibular lymphadenopathy. He endorses having sexual intercourse with multiple female partners without the use of condoms. Physical examination is notable for a perioral papulovesicular lesion without any genital lesions. Introduction Classification login to view 1 more bullet Epidemiology login to view 2 more bullets Transmission login to view 2 more bullets Pathogenesis login to view 15 more bullets Associated conditions login to view 5 more bullets Prognosis login to view 2 more bullets Presentation Symptoms/physical exam login to view 6 more bullets Studies Making the diagnosis login to view 1 more bullet Tzank smear login to view 2 more bullets Real-time HSV PCR assay login to view 1 more bullet Differential Aphthous ulcers login to view 2 more bullets Treatment Medical login to view 4 more bullets Complications HSV encephalitis Pneumonitis HSV esophagitis