Updated: 8/18/2018

Viral Genetics

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Overview
  • Recombination
    • exchange of genes between 2 chromosomes
    • crossing over occurs in homologous regions
  • Reassortment   
    • viruses with segmented genomes exchange segments
    • analagous to high-frequency recombination
    • results in influenza pandemics
  • Complementation
    • 2 viruses infect a cell, but one is mutated and has a non-functional protein
    • the nonmutated virus helps the mutant by making protein for both viruses
  • Phenotypic mixing 
    • 2 viruses infect a cell
    • virus A has its own genetic material, but the surface proteins of virus B
    • progeny viruses contain coat components and genetic material from virus A
      • this is because they only had the genetic material from virus A
    • genetic material is not altered
    • pseudovirion formation
      • when a virus's coat is entirely from another virus
      • nucleic acid and coat are completely mismatched
 

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Questions (5)
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(M1.MC.15.0) A scientist performed an experiment to produce hybrid viruses by mixing two different serotypes of influenza virus, H1N1 and H2N2, in a respiratory epithelium cell line. Several days later, the scientist collected the media and analyzed the viral progeny. She found the following serotypes of virus: H1N1, H2N2, H1N2, and H2N1. Which of the following terms best explains the appearance of new serotypes? Tested Concept

QID: 107005
1

Recombination

27%

(8/30)

2

Reassortment

57%

(17/30)

3

Complementation

0%

(0/30)

4

Phenotypic mixing

3%

(1/30)

5

Transformation

10%

(3/30)

L 1 D

Select Answer to see Preferred Response

(M1.MC.15.10000) Two viruses, X and Y, infect the same cell and begin to reproduce within the cell. As a result of the co-infection, some viruses are produced where the genome of Y is surrounded by the nucleocapsid of X and vice versa with the genome of X and nucleocapsid of Y. When the virus containing genome X surrounded by the nucleocapsid of Y infects another cell, what is the most likely outcome? Tested Concept

QID: 106972
1

Virions containing genome X and nucleocapsid Y will be produced

20%

(10/50)

2

Virions containing genome X and nucleocapsid X will be produced

42%

(21/50)

3

Virions containing genome Y and nucleocapsid Y will be produced

20%

(10/50)

4

Virions containing genome Y and nucleocapsid X will be produced

8%

(4/50)

5

No virions will be produced

4%

(2/50)

L 1 D

Select Answer to see Preferred Response

(M1.MC.14.102) When hepatitis D was injected into an immunocompromised mouse, there was no detectable hepatitis D RNA in the blood at any time point during the next several months. When co-injected with hepatitis B, hepatitis D RNA was was detected in the blood. Which of the following best describes this phenomenon? Tested Concept

QID: 106874
1

Recombination

11%

(6/56)

2

Reassortment

4%

(2/56)

3

Complementation

64%

(36/56)

4

Phenotypic mixing

2%

(1/56)

5

Transduction

12%

(7/56)

L 1 D

Select Answer to see Preferred Response

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Topic COMMENTS (4)
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