Updated: 7/6/2021

Viral Genetics

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Questions
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Evidence
3
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1
Topic
Overview
  • Recombination 
    • exchange of genes between 2 chromosomes
    • crossing over occurs in homologous regions
  • Reassortment   
    • viruses with segmented genomes exchange segments
    • analagous to high-frequency recombination
    • results in influenza pandemics
  • Complementation
    • 2 viruses infect a cell, but one is mutated and has a non-functional protein
    • the nonmutated virus helps the mutant by making protein for both viruses
  • Phenotypic mixing 
    • 2 viruses infect a cell
    • virus A has its own genetic material, but the surface proteins of virus B
    • progeny viruses contain coat components and genetic material from virus A
      • this is because they only had the genetic material from virus A
    • genetic material is not altered
    • pseudovirion formation
      • when a virus's coat is entirely from another virus
      • nucleic acid and coat are completely mismatched

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Questions (5)
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(M1.MC.15.0) A scientist performed an experiment to produce hybrid viruses by mixing two different serotypes of influenza virus, H1N1 and H2N2, in a respiratory epithelium cell line. Several days later, the scientist collected the media and analyzed the viral progeny. She found the following serotypes of virus: H1N1, H2N2, H1N2, and H2N1. Which of the following terms best explains the appearance of new serotypes?

QID: 107005
1

Recombination

27%

(12/45)

2

Reassortment

60%

(27/45)

3

Complementation

0%

(0/45)

4

Phenotypic mixing

4%

(2/45)

5

Transformation

7%

(3/45)

M 1 D

Select Answer to see Preferred Response

(M1.MC.15.10000) Two viruses, X and Y, infect the same cell and begin to reproduce within the cell. As a result of the co-infection, some viruses are produced where the genome of Y is surrounded by the nucleocapsid of X and vice versa with the genome of X and nucleocapsid of Y. When the virus containing genome X surrounded by the nucleocapsid of Y infects another cell, what is the most likely outcome?

QID: 106972
1

Virions containing genome X and nucleocapsid Y will be produced

26%

(20/76)

2

Virions containing genome X and nucleocapsid X will be produced

45%

(34/76)

3

Virions containing genome Y and nucleocapsid Y will be produced

13%

(10/76)

4

Virions containing genome Y and nucleocapsid X will be produced

5%

(4/76)

5

No virions will be produced

5%

(4/76)

M 1 D

Select Answer to see Preferred Response

(M1.MC.14.102) When hepatitis D was injected into an immunocompromised mouse, there was no detectable hepatitis D RNA in the blood at any time point during the next several months. When co-injected with hepatitis B, hepatitis D RNA was was detected in the blood. Which of the following best describes this phenomenon?

QID: 106874
1

Recombination

9%

(6/68)

2

Reassortment

3%

(2/68)

3

Complementation

68%

(46/68)

4

Phenotypic mixing

3%

(2/68)

5

Transduction

12%

(8/68)

M 1 D

Select Answer to see Preferred Response

Evidence (3)
VIDEOS & PODCASTS (1)
EXPERT COMMENTS (4)
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