Updated: 10/18/2016

Drug Resistance

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Overview
  • Penicillin
    • Campylobacter jejuni
    • Enterococcus faecalis
    • Neisseria gonorrohoeae
    • Gram-negative bacilli
      • resistant to benzylpenicillin G
      • outer membrane layer inhibits entry of penicillin G
      • may be susceptible to penicillin derivatives (e.g. ampicillin)
  • Ampicillin
    • Shigella
  • Vancomycin
    • Enterococcus faecalis (vancomycin resistant strains, VRE)
    • VRSA
    • Gram-negative bacilli
      • outer membrane layer inhibits entry of vancomycin
  • Methicillin
    • MRSA
      • via penicillin-binding protein mutation
  • Bacitracin
    • Streptococcus agalacticae
  • Optochin
    • Viridans group Streptococci
  • Ceftriaxone
    • some strains of Streptococcus pneumoniae
  • Amantadine/rimantadine
    • influenza virus
  • Isoniazid + rifampin
    • multi-drug resistant tuberculosis
  • Aminoglycosides
    • do not work against obligate anaerobes
    • aminoglycosides require O2 to enter the cell
  • Chloroquine
    • chloroquine-resistant Plasmodium falciparum malaria
 

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