Overview Overview found in high concentrations in metabolically active cells Cell biology double membrane structure outer membrane high permeability due to high concentration of porins inner membrane impermeable to ions and molecules folded into cristae to ↑ surface area contains enzymes for electron transport chain (ETC) inner matrix contains circular DNA (mtDNA) maternal inheritance as mitochondria in the zygote come from the egg non-Mendelian inheritance synthesized in continous polycistronic manner including 13 coding genes 2 ribosomal RNA modules 22 transfer RNA segments examples of mtDNA disorders Leber's optic neuropathy degeneration of retinal ganglion cells progressive loss of central vision eventual blindness Pearson marrow-pancreas syndrome some protein synthesis occurs here most proteins are synthesized in cytoplasm and translocated to mitochondria Function oxidizes substrates NADH/FADH2 → NAH+/FAD generates ATP converts NADH/FADH2 into ATP via ETC stores Mg2+ and Ca2+ Mitochondrial Inheritance Pedigree Affected males transmit to none of their children Affected females transmit to all of their children
QUESTIONS 1 of 4 1 2 3 4 Previous Next Sorry, this question is for PEAK Premium Subscribers only Upgrade to PEAK Sorry, this question is for PEAK Premium Subscribers only Upgrade to PEAK (M1.BC.14.29) Given the pattern of inheritance shown in the pedigree, where might you find the disease gene in question? QID: 100094 FIGURES: A Type & Select Correct Answer 1 On single-stranded DNA in the cytoplasm 2% (3/175) 2 On circular DNA in the mitochondrion 66% (115/175) 3 On double stranded DNA in the nucleus 7% (13/175) 4 On linear DNA in the mitochondrion 22% (38/175) 5 On helical RNA in the cytoplasm 1% (1/175) M 1 Question Complexity D Question Importance Select Answer to see Preferred Response SUBMIT RESPONSE 2 Review Tested Concept Review Full Topic Sorry, this question is for PEAK Premium Subscribers only Upgrade to PEAK
All Videos (0) Biochemistry | Mitochondria Biochemistry - Mitochondria Listen Now 10:37 min 3/22/2022 32 plays 5.0 (1)