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Updated: Mar 26 2019

Extracellular Matrix

Images
https://upload.medbullets.com/topic/102086/images/ecm1.jpg
  • Overview
    • Components
      • collagen
        • see Collagen topic
      • elastin
        • see Elastin topic
      • glycoproteins
        • structure
          • protein + carbohydrates
            • protein content > carbohydrate content
              • opposite true for proteoglycans
        • function
          • attach cells to various components of the ECM
        • examples
          • entactin
          • tenascin
          • laminin
      • fibronectin
        • structure
          • insoluble monomers
            • involved in linking cell surface integrins to ECM
          • soluble protein
            • assists in blood clotting
        • functions
          • attach cells to various components of the ECM
          • can circulate in plasma to assist with clotting
          • biofilm formation via cell adhesion to basement membranes
      • proteoglycans
        • structure
          • protein + glycosaminoglycan (GAGs)
            • GAGs have large amount of negative charges due to sulfation
            • examples of GAGs
              • chondroitin sulfate
              • dermatan sulfate
              • keratan sulfate
              • heparan sulfate
              • hyaluronic acid
        • function
          • high degree of hydration
            • sponge-like nature resists compression
              • found in high concentrations in cartilage
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