Introduction Function catalyze conversion of pyruvate to acetyl-CoA net reaction pyruvate + NAD+ + CoA → acetyl-CoA + CO2 + NADH irreversible Structure 3 enzymes that require 5 cofactors thiamine pyrophosphate (B1) FAD (B2) NAD (B3) CoA (B5) lipoic acid similar to α-ketoglutarate dehydrogenase complex Regulation activators of pyruvate dehydrogenase ↓ in energy status of the cell login to view 2 more bullets ↑ exercise ↑ Ca2+ ↑ insulin inhibited by acetyl-CoA Clinical relevance pyruvate dehydrogenase deficiency pathophysiology login to view 6 more bullets presentation login to view 1 more bullet treatment login to view 2 more bullets arsenic poisoning inhibits pyruvate dehydrogenase login to view 1 more bullet presentation login to view 3 more bullets