Intermediate Filaments

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Overview

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Structure
- stable polymers
  
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- intermediate in size between microfilaments (7 nm) and microtubules (25 nm)

Function
- give strength to the cytoskeleton
- 5 types

                        TypeFilament nameLocationsStain
I-IIKeratinEpithelial cellsCytokeratin
IIIDesminMuscle (smooth, cardiac, and skeletal)Desmin
PeripherinPeripheral nerve axons -
VimentinFibroblasts and endotheliumVimentin
Glial fibrillary acidic protein (GFAP)Astrocytes and Schawnn cellsGFAP
IVNeurofilamentsNeuronsNeurofilament (NF)
VLaminsNuclear envelope of all cells-

Type	Filament name	Locations	Stain
I-II	Keratin	Epithelial cells	Cytokeratin
III	Desmin	Muscle (smooth, cardiac, and skeletal)	Desmin
	Peripherin	Peripheral nerve axons	-
	Vimentin	Fibroblasts and endothelium	Vimentin
	Glial fibrillary acidic protein (GFAP)	Astrocytes and Schawnn cells	GFAP
IV	Neurofilaments	Neurons	Neurofilament (NF)
V	Lamins	Nuclear envelope of all cells	-

Clinical importance
- alcoholic liver disease
  
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- Parkinson's disease
  
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Biochemistry | Intermediate Filaments

Biochemistry
- Intermediate Filaments

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