Overview Purine salvage pathway see figure clinical importance adenosine deaminase (ADA) deficiency login to view 8 more bullets Lesch-Nyhan disease login to view 11 more bullets gout login to view 20 more bullets Pyrimidine salvage may be salvaged by pyrimidine salvage enzymes degradation completely broken down to ammonia Other causes of hyperuricemia ↑ EtOH intake can precipitate an acute gout attack ↑ nucleic acid in diet red meats, organ meats phosphate "trapping" diseases e.g. glucose-6-phosphate deficiency (G6PD), galactose uridyltransferase deficiency caused by an inability to dephosphorylate common metabolites and therefore leads to trapping of phosphate by these metabolites lack of phosphate prevents synthesis of ATP, GTP, plus other nucleotide phosphates ADP. AMP, and other hypophosphorylated bases are salvaged producing uric acid