Please confirm topic selection

Are you sure you want to trigger topic in your Anconeus AI algorithm?

Updated: May 1 2017

Nucleic Acid Structure

  • Overview
    • Nitrogenous bases
      • purines
        • structure
          • 2 rings
        • examples
          • adenine (A), guanine (G)
            • found in DNA and RNA
          • xanthine, hypoxanthine, uric acid
            • not found in either DNA or RNA
      • pyrimidines
        • structure
          • 1 ring
        • examples
          • cytosine (C)
            • found in DNA and RNA
          • thymine (T)
            • found in DNA
          • uracil (U)
            • found in RNA
    • Nucleoside
      • nitrogenous base + ribose
    • Nucelotide
      • nitrogenous base + ribose + phosphate
        • 3'-5' phosphodiester bond connects ribose and phosphate
    • DNA
      • nucleotide interactions
        • H-bonding
          • G with C
            • 3 H-bonds
            • stronger
          • A with T
            • 2 H-bonds
            • weaker
            • A with U in RNA
        • melting or denaturing
          • H-bonds disrupted with changes in temperature, pH, chemical agents
          • ↑ GC content = ↑ melting temperature
          • DNA can form correct structure again if disrupting agent is removed slowly (reanealing)
            • key principle of Southern blotting and PCR
            • see Biological lab techniques section
      • strands
        • antiparallel
        • right handed double helix
      • Chargaff's rules
        • A % = T/U %
        • G % = C %
    • Clinical importance
      • anticancer drugs
        • can intercalate DNA
          • daunorubicin, doxorubicin
        • can bind DNA
          • cisplatin
Card
1 of 0
Private Note

Attach Treatment Poll
Treatment poll is required to gain more useful feedback from members.
Please enter Question Text
Please enter at least 2 unique options
Please enter at least 2 unique options
Please enter at least 2 unique options