Review Question - QID 210591

A 23-year-old woman presents to her primary care physician because she has been having difficulty seeing despite previously having perfect vision all her life. Specifically, she notes that reading, driving, and recognizing faces has become difficult, and she feels that her vision has become fuzzy. She is worried because both of her older brothers have had visual loss with a similar presentation. Visual exam reveals bilateral loss of central vision with decreased visual acuity and color perception. Pathological examination of this patient's retinas reveals degeneration of retinal ganglion cells bilaterally. She is then referred to a geneticist because she wants to know the probability that her son and daughter will also be affected by this disorder. Her husband's family has no history of this disease. Ignoring the effects of incomplete penetrance, which of the following are the chances that this patient's children will be affected by this disease?