Overview Structure two types login to view 4 more bullets 1 ketone body = 2 acetyl-CoA Function produced by the liver login to view 2 more bullets can provide energy to body in prolonged energy needs login to view 2 more bullets can provide energy if citric acid cycle unable to function login to view 5 more bullets RBCs cannot use ketones as they lack mitochondria Synthesis occurs in hepatocyte mitochondria login to view 2 more bullets under normal conditions acetoacetate = β-hydroxybutyrate HMG CoA synthase is rate limiting enzyme Clinical relevance ketoacidosis login to view 25 more bullets