Overview Function generate NADPH required for FA synthesis, steroid synthesis, reduction of oxidizing agents (H2O2 see figure) provide ribose 5-phosphate required for nucleotide synthesis Pathway occurs in cytoplasm of all cells no ATP consumed or generated 2 phases oxidative login to view 7 more bullets nonoxidative login to view 4 more bullets Clinical relevance glucose-6-phosphate dehydrogenase (G6PDH) deficiency pathophysiology login to view 11 more bullets presentation login to view 18 more bullets test login to view 2 more bullets