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Updated: May 2 2017


  • Overview
    • Nuclear envelope
      • membrane bilayer structure
        • continuous with ER
        • contains nuclear pores
          • controls transport between cytoplasm and nucleus
          • more active cells have more nuclear pores
          • small molecules freely traffic
          • large molecules require active transport
            • mediated by importins and exportins
            • nuclear localization signal (NLS) provides signal for nuclear access
    • Nuclear lamina
      • on inner face of nuclear envelope
      • fibrous network of proteins
      • role
        • attach to chromatin
        • participate in construction and deconstruction of nucleus during cell division
          • phosphorylation by lamin kinase in prophase results in blebbing of nuclear envelope
    • Nucleolus
      • location of rRNA synthesis
      • site of ribosomal assembly
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