Please confirm topic selection

Are you sure you want to trigger topic in your Anconeus AI algorithm?

Please confirm action

You are done for today with this topic.

Would you like to start learning session with this topic items scheduled for future?

Updated: Dec 25 2021

Fructose Metabolism

  • Overview
    • Source
      • sucrose in fruits and sweeteners
        • disaccharide of glucose and fructose
        • hydrolyzed by sucrase in brush border of small intestine
    • Pathway
      • liver is main site of metabolism
        • also in renal proximal tubule
      • DHAP and glyceraldehyde enter into glycolysis downstream of regulation
    • Clinical relevance
      • fructokinase deficiency
        • benign
        • presentation
          • fructosuria
          • does not have the osmotic pathologies (e.g. cataracts) associated with galactokinase deficiencies
            • fructose is not an aldose and therefore not substrate for aldose reductase
      • fructose 1-P aldolase (aldolase B) deficiency
        • aka hereditary fructose intolerance
        • AR
        • more severe than fructokinase deficiency because fructose 1-P acts as a phosphate sink
        • presentation
          • fructosuria
          • lethargy
          • hypoglycemia
          • liver and proximal renal tubule disorder
            • hyperbilirubinemia
            • hyperuricemia
              • degradation of ADP due to loss of Pi
        • treatment
          • fructose (and sucrose)-free diet
Card
1 of 0
Question
1 of 3
Private Note