Please confirm topic selection

Are you sure you want to trigger topic in your Anconeus AI algorithm?

Updated: Aug 10 2019

Propionic Acid Pathway

  • Overview
    • Production
      • β-oxidation of odd-numbered fatty acids
        • 2 carbon acetyl-CoA groups removed from chain until there are 5 carbons remaining
        • 5 carbon chain split into 1 acetyl-CoA (2C) + 1 propionyl-CoA (3C)
    • Pathway
      • propionyl-CoA → methylmalonyl-CoA
        • catalyzed by propionyl-CoA carboxylase
          • requires biotin (B7)
      • methylmalonyl-CoA → succinyl-CoA
        • catalyzed by methylmalonyl-CoA mutase
          • requires B12
        • deficiency of B12 results in a blockage of this step
          • result is ↑↑↑ methylmalonate
          • can cause irreversible neuropathy
            • due to pathologic synthesis of myelin with methylmalonate
          • a means to determine whether a patient with megaloblastic anemia is deficient in folate or B12
            • methylmalonic aciduria not see in folate deficiencies
      • succinyl-CoA → citric acid cycle
        • can be converted to malate
          • is gluconeogenic
            • exception to rule that fatty acids can be converted to glucose
Card
1 of 0
Question
1 of 2
Private Note

Attach Treatment Poll
Treatment poll is required to gain more useful feedback from members.
Please enter Question Text
Please enter at least 2 unique options
Please enter at least 2 unique options
Please enter at least 2 unique options