Overview Production β-oxidation of odd-numbered fatty acids 2 carbon acetyl-CoA groups removed from chain until there are 5 carbons remaining 5 carbon chain split into 1 acetyl-CoA (2C) + 1 propionyl-CoA (3C) Pathway propionyl-CoA → methylmalonyl-CoA catalyzed by propionyl-CoA carboxylase login to view 1 more bullet methylmalonyl-CoA → succinyl-CoA catalyzed by methylmalonyl-CoA mutase login to view 1 more bullet deficiency of B12 results in a blockage of this step login to view 5 more bullets succinyl-CoA → citric acid cycle can be converted to malate login to view 2 more bullets