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Updated: Mar 1 2017

Microarrays

  • Overview
    • Function
      • can probe for thousands of different mRNAs simultaneously
    • Process
      • a chip has thousands of DNA sequences robotically attached on a grid
      • a solution of degraded mRNA is added to the chip
      • thousands of probes are added
      • a computer analyzes the degree of binding to various regions of the chip
    • Clinical use
      • analyze cancer cell gene expression
        • can determine probability of becoming malignant based on population comparison studies
        • can be used to guide therapy
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