Updated: 5/2/2017

Nucleus

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Overview
  •  Nuclear envelope
    • membrane bilayer structure
      • continuous with ER
      • contains nuclear pores
        • controls transport between cytoplasm and nucleus
        • more active cells have more nuclear pores
        • small molecules freely traffic
        • large molecules require active transport
          • mediated by importins and exportins
          • nuclear localization signal (NLS) provides signal for nuclear access
  • Nuclear lamina
    • on inner face of nuclear envelope
    • fibrous network of proteins
    • role
      • attach to chromatin
      • participate in construction and deconstruction of nucleus during cell division
        • phosphorylation by lamin kinase in prophase results in blebbing of nuclear envelope
  • Nucleolus
    • location of rRNA synthesis 
    • site of ribosomal assembly
 

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