Updated: 3/26/2019

Extracellular Matrix

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Overview
  •  Components This illustration highlights the basic components of the extracellular matrix
    • collagen
      • see Collagen topic
    • elastin
      • see Elastin topic
    • glycoproteins
      • structure
        • protein + carbohydrates 
          • protein content > carbohydrate content
            • opposite true for proteoglycans
      • function
        • attach cells to various components of the ECM
      • examples
        • entactin
        • tenascin
        • laminin
    • fibronectin 
      • structure
        • insoluble monomers
          • involved in linking cell surface integrins to ECM
        • soluble protein
          • assists in blood clotting
      • functions
        • attach cells to various components of the ECM
        • can circulate in plasma to assist with clotting
        • biofilm formation via cell adhesion to basement membranes
    • proteoglycans
      • structure
        • protein + glycosaminoglycan (GAGs)
          • GAGs have large amount of negative charges due to sulfation
          • examples of GAGs
            • chondroitin sulfate
            • dermatan sulfate
            • keratan sulfate
            • heparan sulfate
            • hyaluronic acid
      • function
        • high degree of hydration
          • sponge-like nature resists compression
            • found in high concentrations in cartilage

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