Overview Structure stable polymers unlike microtubules and actin → does not undergo dynamic treadmilling must be degraded via the ubiquitin pathway login to view 1 more bullet intermediate in size between microfilaments (7 nm) and microtubules (25 nm) Function give strength to the cytoskeleton 5 types TypeFilament nameLocationsStainI-IIKeratinEpithelial cellsCytokeratinIIIDesminMuscle (smooth, cardiac, and skeletal)DesminPeripherinPeripheral nerve axons -VimentinFibroblasts and endotheliumVimentinGlial fibrillary acidic protein (GFAP)Astrocytes and Schawnn cellsGFAPIVNeurofilamentsNeuronsNeurofilament (NF)VLaminsNuclear envelope of all cells- Clinical importance alcoholic liver disease ubiquitinated cytokeratin filaments accumulate in hepatocytes login to view 1 more bullet Parkinson's disease alpha-synuclein and ubiquitinated neurofilaments accumulate in neurons of substantia nigra eosinophilic inclusions called Lewy bodies