Overview Function detect the presence/location of a specific region of DNA in the genome Process a probe for a desired DNA sequence is created with a fluorescent tag probe is added to DNA sample and color is detected, usually with chromosomes in metaphase (condensed and coiled) Clinical use detect microdeletions, translocations, and aneuploidies ex.) a probe for chromosome 7 would only have one signal if the patient had a monosomy as opposed to 2 in a normal sample can also be used to diagnose Prader-Willi syndrome (15q) deletion
All Videos (1) Login to View Community Videos Login to View Community Videos FISH Keshav Mudgal Biochemistry - Fluorescence In Situ Hybridization (FISH) D 1/13/2016 111 views 5.0 (3)