Updated: 11/28/2019

Reverse Transcription

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Overview
  • Function
    • convert RNA to DNA
    • performed by reverse transcriptase
      • has high error rate and cannot proofread
      • three activities
        • RNA-dependent DNA polymerase
        • RNase
        • DNA-dependent DNA polymerase
  • Clinical relevance
    • present in retroviruses 
      • e.g. HIV
        • some HIV drugs inhibit reverse transcriptase 
          • AZT 
            • enters cells and modified by addition of ATP
            • functions as a nucleoside analog
            • terminates replication
    • present in telomerase
      • see Telomere topic
    • used in RT-PCR
      • see PCR topic
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