Linkage Analysis Principles linkage the rate of cosegregation of two syntenic alleles (alleles appearing on the same chromosome) is inversely proportional to the distance between the alleles login to view 2 more bullets linkage group set of genes at different loci on the same chromosome that tend to act as a single set of genes in meiosis rather than undergoing independent assortment login to view 1 more bullet linkage analysis using a pedigree to determine the location of an allele based on the rate of cosegregation with other alleles of known location (genetic markers) can be used to track disease-causing mutation login to view 1 more bullet centi-Morgan (cM): a unit used to measure genetic linkage a length of DNA over which the frequency of homologous recombination is 1% login to view 2 more bullets parental gamete the portion of chromosome looks the same as that of one of the parents no recombination nonparental gamete homologous recombination has occurred in the region of interest linkage disequilibrium when alleles occur together more often than can be accounted for by chance login to view 1 more bullet