Updated: 12/22/2016

Metabolism Overview

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Summary of Pathways

 

 
 
Rate Determining Enzymes
 
Process Enzyme
Glycolysis Phosphofructokinase-1 (PFK-1)
Gluconeogenesis Fructose-1,6-bisphosphatase
TCA cycle Isocitrate dehydrogenase
Glycogen synthesis Glycogen synthase
Glycogenolysis Glycogen phosphorylase
HMP shunt Glucose-6-phosphate dehydrogenase (G6PD)
De novo pyrimidine synthesis Carbamoyl phosphate synthetase II
De novo purine synthesis Glutamine-PRPP amidotransferase
Urea cycle Carbamoyl phosphate synthetase I
Fatty acid synthesis Acetyl-CoA carboxylase (ACC)
Fatty acid oxidation Carnitine acyltransferase I
Ketogenesis HMG-CoA synthetase
Cholesterol synthesis HMG-CoA reductase 

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