Introduction Testicular tumors can be of germ cell or non-germ cell origin germ cell origin are the majority (95%) and are more commonly malignant non-germ cell origin usually benign Epidemiology incidence most common cancer in men between 15-35 years risk factors cryptorchidism Klinefelter syndrome testicular feminization Classification Germ cell types seminoma malignant most common testicular tumor mostly affecting males 15-35 years commonly metastasizes to para-aortic lymph nodes before hematogenous spread embryonal carcinoma malignant commonly metastasizes early yolk sac (endodermal sinus) tumor seen in children < 4 years choriocarcinoma malignant teratoma mature teratoma in males is most often malignant unlike females Non-germ cell types Leydig cell (sex-cord stromal) Sertoli cell (sex-cord stromal) Testicular lymphoma most common testicular cancer in older men involves both testes Presentation Symptoms painless unilateral enlargement of testes seminoma homogenous testicular enlargement embryonal carcinoma painful choriocarcinoma gynecomastia due to hCG production which is an LH analogue Leydig cell usually androgen producing gynecomastia in men precocious puberty in boys Physical exam solid mass of the testes is always cancer Evaluation Histology seminoma large cells in lobules with watery cytoplasm "fried egg" analogous to dysgerminoma of the ovary embryonal carcinoma glandular/papillary yolk sac (endodermal sinus) tumor yellow, mucinous Schiller-Duval bodies resemble primitive glomeruli choriocarcinoma disordered syncytiotrophoblastic and cytotrophoblastic elements teratoma contain three tissue types leydig cell contains Reinke crystals golden brown color Serology LDH non-specific specific tumor markers embryonal carcinoma ↑ AFP and hCG yolk sac (endodermal sinus) tumor ↑ AFP choriocarcinoma ↑ hCG Treatment Pharmacologic & radiation radiation therapy indications seminoma is radiosensitive Surgical orchiectomy Prognosis Seminoma late metastasis and excellent prognosis Embryonal worse prognosis than seminoma Choriocarcinoma worst prognosis in contrast to good prognosis in females metastasizes to lungs
QUESTIONS 1 of 3 1 2 3 Previous Next Sorry, this question is for PEAK Premium Subscribers only Upgrade to PEAK (M1.ON.14.57) A 45-year-old man presents to his primary care provider for his yearly physical. On exam, the physician discovers a hard, testicular mass on the right testis. On further questioning, the patient remarks that he first noticed it 6 months ago, but did not think he needed to have it examined since it wasn't painful. Transillumination of the scrotum does not reveal translucency. The ultrasound of his right testis is shown in Figure A. Blood work reveals normal AFP and Beta-hCG. Chest radiograph and CT scan do not show positive lymph nodes or distant metastases. Which of the following is the most appropriate next step? Tested Concept QID: 106375 FIGURES: A Type & Select Correct Answer 1 Biopsy 47% (8/17) 2 Radical orchiectomy 41% (7/17) 3 Chemotherapy 6% (1/17) 4 Three month re-imaging 6% (1/17) 5 No further workup, instruct patient to return if symptomatic 0% (0/17) M 3 Question Complexity E Question Importance Select Answer to see Preferred Response SUBMIT RESPONSE 2 Review tested concept Sorry, this question is for PEAK Premium Subscribers only Upgrade to PEAK
All Videos (1) Login to View Community Videos Login to View Community Videos Yolk Sac (Endodermal Sinus) Tumor Oncology - Testicular Tumors D 4/10/2019 43 views 5.0 (1)