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Updated: Jul 5 2016

Penis Cancer

  • Introduction
    • May have carcinoma in situ (CIS) or squamous cell carcinoma (SCC)
      • carcinoma in situ
        • Bowen's disease
          • leukoplakia on the shaft of the penis or scrotum
          • peak incidence > 50 years
          • associated with HPV 16
          • minority of cases progresses to SCC
        • Erythroplasia of Queyrat
          • erythroplakia on the glans/prepuce
          • only the location distinguishes Bowen's from Queyrat's
        • Bowenoid papulosis
          • multiple papular lesions
          • affects at a younger age than Bowden/Queyrat
          • associated with HPV 16
          • does not progress to SCC
      • Squamous cell carcinoma (SCC)
        • more common in Asia, Africa, and South America
        • most common sites are prepuce/glans
        • commonly associated with
          • HPV 16 and 18
          • smoking
          • lack of circumcision
            • increases risk only if man is not hygienic
  • Prognosis, Prevention, and Complications
    • Metastasis
      • SCC may seed to inguinal and iliac nodes
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