Overview Targeted Therapy Drugs/Antibodies Mechanism of Action Toxicity Hydroxyurea Inhibits ribonucleotide reductase GI upset and myelosupression Trastuzumab Anti-HER-2 (erb-B2) monoclonal antibody Cardiotoxicity Tamoxifen and raloxifene Selective estrogen receptor modulator ↑ risk of endometrial carcinoma and hot flashes Imatinib bcr-abl tyrosine kinase inhibitor Fluid retention Rituximab anti-CD20 monoclonal antibody - Vemurafenib Inhibitor of BRAF - Hydroxyurea Mechanism login to view 3 more bullets Clinical use login to view 4 more bullets Toxicity login to view 2 more bullets Trastuzumab (Herceptin) Mechanism login to view 1 more bullet Clinical use login to view 1 more bullet Toxicity login to view 1 more bullet Tamoxifen, raloxifene Mechanism login to view 4 more bullets Clinical use login to view 2 more bullets Toxicity login to view 5 more bullets Imatinib (Gleevec) Mechanism login to view 2 more bullets Clinical use login to view 2 more bullets Toxicity login to view 1 more bullet Rituximab Mechanism login to view 2 more bullets Clinical use login to view 4 more bullets