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Updated: Feb 13 2018

Oncogenes

  • Overview
    • Mechanism
      • gain of function mutation in a proto-oncogene
      • due to novel protein function only one allele change needed for neoplasia
    • Categories of proto-oncogenes
      • growth factor overproduction
      • growth factor receptor upregulation
        • e.g., HER2/neu
      • signal transducer
        • e.g., ras
      • cell cycle regulators
    • Examples
      • Oncogene
      • Gene
      • Associated Tumor
      • Mechanism
      • BCR:ABL
      • CML
      • 9;22 translocation
      • BCL-2
      • Follicular and undifferentiated lymphomas
      • 14;18 translocation
      • CCND1
      • Mantle cell lymphomas
      • 11;14 translocation
      • C-Myc
      • Burkitt's lymphoma
      • 8;14 translocation
      • L-Myc
      • Lung tumor
      • amplification
      • N-MYC
      • Neuroblastoma
      • amplification
      • ERB-B2
      • Breast, ovarian, and gastric carcinomas
      • amplification
      • CDK4
      • Melanoma
      • amplification
      • RET
      • Multiple endocrine neoplasia IIA and B
      • point mutation
      • C-KIT
      • Gastrointestinal stromal tumor (GIST)
      • point mutation
      • RAS
      • Colon carcinoma
      • point mutation
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