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Updated: Dec 11 2016

Platinum Analogs

  • Cisplatin and Carboplatin
    • Mechanism
      • crosslinks DNA
        • platinum atom binds to DNA bases
    • Clinical use
      • testicular cancer
      • bladder cancer
      • ovarian cancer
      • lung cancer
    • Toxicity
      • nephrotoxicity
        • prevent with
          • amifostine
            • free radical scavenger
          • hydration
      • deafness
        • acoustic nerve damage
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