Vinca Alkaloids (Vincristine and Vinblastine) Mechanism block microtubule formation bind to tubulin in M phase prevent polymerization of microtubules prevent formation of mitotic spindle Clinical use Hodgkin's lymphoma part of the MOPP regimen login to view 4 more bullets Wilms' tumor choriocarcinoma ALL testicular cancer Kaposi's sarcoma Toxicity vincristine neurotoxicity login to view 3 more bullets vinblastine myelosuppression Taxols (Paclitaxel) Mechanism block microtubule breakdown hyperstabilize microtubules in M phase mitotic spindle cannot break down anaphase cannot occur Clinical use ovarian cancer breast cancer Toxicity peripheral neuropathy myelosuppression hypersensitivity