Snapshot A 69-year-old man presents to the emergency department with generalized fatigue and abdominal pain. He has had a 20-pound weight loss over the course of 3 months. He has a past medical history of alcohol use disorder and longstanding diabetes. He also has been smoking 1 pack of cigarettes for the past 50 years. Physical examination is notable for scleral icterus and abdominal tenderness to palpation in the epigastric region. CT abdomen with and without contrast demonstrates a mass at the head of the pancreas. Introduction Overview login to view 7 more bullets Epidemiology login to view 10 more bullets Etiology login to view 2 more bullets Pathogenesis login to view 2 more bullets Prognosis login to view 1 more bullet Presentation Symptoms login to view 5 more bullets Physical exam login to view 4 more bullets Imaging Abdominal ultrasound login to view 3 more bullets Abdominal CT scan login to view 3 more bullets Endoscopic retrograde cholangiopancreatography (ERCP) login to view 3 more bullets Endoscopic ultrasonography login to view 3 more bullets Studies Serum labs login to view 5 more bullets Differential Acute pancreatitis login to view 2 more bullets Gastric cancer login to view 2 more bullets Treatment Treatment depends on the stage of the pancreatic cancer Surgical login to view 3 more bullets Complications Obstructive cholestasis Gastric outlet obstruction Diabetes Migratory thrombophlebitis