Genetic Diseases Genetic Diseases Condition Neoplasm Down syndrome ALL (presents > 5 years old) and AML- megakaryoblastic (< 5 years old) Xeroderma pigmentosum Melanoma, basal cell carcinoma, and squamous cell carcinomas of skin Albinism Melanoma, basal cell carcinoma, and squamous cell carcinomas of skin Tuberous sclerosis Astrocytoma, angiomyolipoma, and cardiac rhabdomyoma Disease Resulting From Environmental Exposure Disease Resulting From Environmental Exposure Condition Neoplasm Actinic keratosis Squamous cell carcinoma of skin Barrett's esophagus Esophageal adenocarcinoma Dysplastic nevus Malignant melanoma Radiation exposure AML, CML, and papillary thyroid cancer Diseases Associated with the Immune System Diseases Associated with the Immune System Condition Neoplasm Ulcerative colitis Colonic adenocarcinoma Immunodeficiency Malignant lymphomas AIDS Malignant lymphomas and Kaposi's sarcoma HPV High risk types (16,18,31,33) Squamous cell carcinoma Autoimmune diseases (e.g. Hashimoto's thyroiditis and myasthenia gravis) Lymphoma (marginal cell type) Miscellaneous Diseases Miscellaneous Diseases Condition Neoplasm Plummer-Vinson syndrome Squamous cell carcinoma of esophagus Cirrhosis (alcoholic, hepatitis B or C) Hepatocellular carcinoma Paget's disease of bone Secondary osteosarcoma and fibrosarcoma Acanthosis nigricans Visceral malignancy (stomach, lung, breast, and uterus)