Overview Ewing Sarcoma Introduction anaplastic small blue cell tumor neuroectoderm origin involves an 11;22 translocation boys < 15 has highest incidence most often seen in diaphysis of long bones, pelvis, scapula, and ribs Evaluation layered "onion-skin" deposition of bone Prognosis, Prevention, and Complications early metastasis responsive to chemotherapy Chondrosarcoma Introduction malignant cartilaginous tumor seen in men 30-60 years most commonly involves the central skeleton may occur de novo or from progression of osteochondroma Evaluation expansile glistening mass located in the medullary cavity Osteosarcoma (osteogenic sarcoma) Introduction tumor of osteoblasts most common primary malignant tumor of bone commonly found in the metaphysis of long bones e.g. distal femur or proximal tibia risk factors Paget disease of bone results in onset in elderly bone infarcts radiation familial retinoblastoma Rb mutation results in onset before third decade Evaluation histology large pleomorphic cells producing increased osteoid Radiograph Codman's triangle or sunburst pattern from elevation of periosteum from the cortical bone Prognosis, Prevention, and Complications poor prognosis Bone Metastasis Introduction typically result in osteolytic lesions exception is prostatic carcinoma produces osteoblastic lesion
QUESTIONS 1 of 7 1 2 3 4 5 6 7 Previous Next Sorry, this question is for PEAK Premium Subscribers only Upgrade to PEAK Sorry, this question is for PEAK Premium Subscribers only Upgrade to PEAK Sorry, this question is for PEAK Premium Subscribers only Upgrade to PEAK Sorry, this question is for PEAK Premium Subscribers only Upgrade to PEAK (M1.ON.17.4723) A 12-year-old Caucasian male presents with his mother to the pediatrician’s office complaining of right thigh pain. He reports that he has noticed slowly progressive pain and swelling over the distal aspect of his right thigh over the past two months. He denies any recent trauma to the area and his temperature is 100.9°F (38.3°C). On exam, there is swelling and tenderness overlying the distal right femoral diaphysis. Laboratory evaluation is notable for an elevated white blood cell (WBC) count and elevated erythrocyte sedimentation rate (ESR). A radiograph of the patient’s right leg is shown. Biopsy of the lesion demonstrates sheets of monotonous small round blue cells with minimal cytoplasm. Which of the following genetic mutations is most likely associated with this patient’s condition? QID: 108547 FIGURES: A Type & Select Correct Answer 1 t(8;14) 12% (33/273) 2 t(11;22) 55% (151/273) 3 APC inactivation 7% (18/273) 4 TP53 inactivation 8% (21/273) 5 RB1 inactivation 15% (40/273) M 1 Question Complexity C Question Importance Select Answer to see Preferred Response SUBMIT RESPONSE 2 Review Tested Concept Review Full Topic Sorry, this question is for PEAK Premium Subscribers only Upgrade to PEAK Sorry, this question is for PEAK Premium Subscribers only Upgrade to PEAK
All Videos (1) Login to View Community Videos Login to View Community Videos Osterosarcoma Keshav Mudgal Oncology - Malignant Bone Tumors E 5/12/2016 60 views 5.0 (1) Oncology | Malignant Bone Tumors Oncology - Malignant Bone Tumors Listen Now 18:20 min 6/25/2021 13 plays 3.0 (1)