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Review Question - QID 210409

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QID 210409 (Type "210409" in App Search)
A 13-year-old Caucasian boy presents with his mother to the pediatrician's office for right arm pain. He reports that he has noticed slowly progressive pain and swelling over the middle of his right arm over the past two months. He denies any recent trauma to the area. He is otherwise healthy and takes no medications. His temperature is 99.8°F (37.7°C), blood pressure is 115/65 mmHg, pulse is 89/min, and respirations are 16/min. On exam, there is swelling and tenderness overlying the right humeral diaphysis. Laboratory evaluation is shown below:

Serum:
Hemoglobin: 15.1 g/dL
Hematocrit: 42%
Leukocyte count: 13,000/mm^3 with normal differential
Platelet count: 210,000/mm^3
Erythrocyte sedimentation rate: 40 mm/hr (normal 0-22 mm/hr)

A radiograph of the patient's right arm is shown in Figure A. Which of the following genetic mutations is associated with this patient's condition?
  • A
  • A