Snapshot A 15-year-old boy presents with fatigue and masses around his neck. The masses are small, mobile, and do not hurt. A few months ago, he had had an episode of infectious mononucleosis. He is referred for a lymph node biopsy, which comes back with positive Reed-Sternberg cells. Introduction B-cell malignancy originating in lymphatic system Pathogenesis login to view 3 more bullets Epidemiology login to view 4 more bullets Types of Hodgkin lymphoma login to view 8 more bullets Risk factors login to view 1 more bullet Presentation Symptoms login to view 6 more bullets Physical exam login to view 6 more bullets Evaluation Imaging for staging Lymph node biopsy login to view 6 more bullets Differential Diagnosis Non-Hodgkin lymphoma AIDS-related lymphadenopathy Infection Breast cancer Cat-scratch fever Treatment Based on staging Chemotherapy Radiation Prognosis, Prevention, and Complications Prognosis login to view 5 more bullets Complications login to view 7 more bullets