Please confirm topic selection

Are you sure you want to trigger topic in your Anconeus AI algorithm?

Please confirm action

You are done for today with this topic.

Would you like to start learning session with this topic items scheduled for future?

Review Question - QID 108772

In scope icon M 2 C
QID 108772 (Type "108772" in App Search)
A 52-year-old female presents to her primary care physician complaining of fever, chills, and night sweats. She says that these symptoms have been present for several months but appear to be getting worse. Her past medical history is significant for mild hypertension and pre-diabetes. She has otherwise been healthy and does not currently take any medications. Physical examination reveals supraclavicular lymphadenopathy. A lymph node biopsy is performed and the result is shown in Figure A. Which of the following cell surface markers is most likely found on the prominent abnormal cell seen in the figure?
  • A

CD3

4%

12/327

CD4

7%

23/327

CD8

8%

25/327

CD16

9%

29/327

CD30

71%

231/327

  • A

Select Answer to see Preferred Response

bookmode logo Review TC In New Tab

The most likely diagnosis in this patient is Hodgkin lymphoma. The biopsy demonstrates a Reed-Sternberg cell, a classic finding in Hodgkin lymphoma that is CD15+ and CD30+.

In this patient with systemic symptoms and lymphadenopathy, lymphoma should be high on the differential diagnosis. The presence of a Reed-Sternberg cell on histology further suggests that this patient likely has Hodgkin lymphoma. Hodgkin lymphoma is a neoplasm of large B cells (Reed-Sternberg cells) that are CD15+ and CD30+. These cells secrete pro-inflammatory cytokines and create a large inflammatory cell infiltrate. Clinically, Hodgkin lymphoma presents with classic “B symptoms” like unexplained fever, chills, night sweats, and weight loss. The prognosis of Hodgkin lymphoma is determined by the lymphocyte:Reed-Sternberg cell ratio – the more lymphocytes present per Reed-Sternberg cell, the better the prognosis.

Figure A demonstrates the classic histologic appearance of Hodgkin lymphoma. Note the presence of the large Reed-Sternberg cell with “owl-eyed” nuclei in a background of inflammatory cells.

Incorrect Answers:
Answer 1: CD3 is a T-cell-specific marker that is part of the T-cell receptor complex. It is not found on B-cells.

Answer 2: CD4 is a T-cell-specific marker that serves as a co-receptor for the T-cell receptor by binding to the class II major histocompatibility complex (MHC) molecule. It is found exclusively on helper T cells and is not found on B-cells.

Answer 3: CD8 is a T-cell-specific marker that serves as a co-receptor for the T-cell receptor by binding to the class I major histocompatibility complex (MHC) molecule. It is found exclusively on cytotoxic T-cells and is not found on B-cells.

Answer 4: CD16 is a low-affinity Fc receptor found on the surface of natural killer (NK) cells. Binding of CD16 to the Fc portion of IgG antibodies activates NK cell antibody-dependent cell-mediated cytotoxicity. CD16 is not found on B-cells.

Bullet Summary:
Hodgkin lymphoma is a B-cell neoplasm that is characterized by CD15+/CD30+ Reed-Sternberg cells and presents with "B symptoms" such as fever, chills, and night sweats.

Authors
Rating
Please Rate Question Quality

4.6

  • star icon star icon star icon
  • star icon star icon star icon
  • star icon star icon star icon
  • star icon star icon star icon
  • star icon star icon star icon

(10)

Attach Treatment Poll
Treatment poll is required to gain more useful feedback from members.
Please enter Question Text
Please enter at least 2 unique options
Please enter at least 2 unique options
Please enter at least 2 unique options