Updated: 3/11/2020

Tumor Suppressor Genes

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                        Overview
                    
                        Mechanism
                    
                        loss of function mutation in a tumor suppressor gene 
                    
                        regulate cell growth and repair damage
                    
                        see Cell cycle topic
                    
                        because one functioning tumor suppressor gene copy can produce enough functioning protein to prevent neoplasia, two allele  alterations needed for neoplasia 
                    
                        two-hit model
                    
                        note many of the inherited cancer disorders have an inherited loss of 1 copy
                    
                        Examples
                    
                        GeneAssociated TumorChromosome
APCColorectal cancer (associated with FAP)5
p16Melanoma9
WT1Wilms' tumor11
RbRetinoblastoma and osteosarcoma13
BRCA2Breast cancer13
NF1Neurofibromatosis type 117
BRCA1Breast and ovarian cancer17
TP53Most human cancers and Li-Fraumeni syndrome17
DPCPancreatic cancer (stands for deleted in pancreatic cancer)18
DCCColon cancer (stands for deleted in colon cancer)18
NF2Neurofibromatosis type 222

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Action	Numeric Key	Letter Key	Function Key
Show Bullets		S	Enter (frontside only)
20%	1	N
40%	2	H
60%	3	F	Enter (backside only)
80%	4	E
100%	5	M
Toss	0	T

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