Overview Mechanism loss of function mutation in a tumor suppressor gene regulate cell growth and repair damage see Cell cycle topic because one functioning tumor suppressor gene copy can produce enough functioning protein to prevent neoplasia, two allele alterations needed for neoplasia two-hit model note many of the inherited cancer disorders have an inherited loss of 1 copy Examples GeneAssociated TumorChromosomeAPCColorectal cancer (associated with FAP)5p16Melanoma9WT1Wilms' tumor11RbRetinoblastoma and osteosarcoma13BRCA2Breast cancer13NF1Neurofibromatosis type 117BRCA1Breast and ovarian cancer17TP53Most human cancers and Li-Fraumeni syndrome17DPCPancreatic cancer (stands for deleted in pancreatic cancer)18DCCColon cancer (stands for deleted in colon cancer)18NF2Neurofibromatosis type 222
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All Videos (2) Login to View Community Videos Login to View Community Videos Li-Fraumeni Syndrome Oncology - Tumor Suppressor Genes D 8/12/2018 139 views 5.0 (4) Login to View Community Videos Login to View Community Videos Tumor suppressors Oncology - Tumor Suppressor Genes E 2/14/2015 80 views 0.0 (0) Oncology | Tumor Suppressor Genes Oncology - Tumor Suppressor Genes Listen Now 10:59 min 2/13/2022 33 plays 5.0 (1)