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Updated: Mar 11 2020

Tumor Suppressor Genes

  • Overview
    • Mechanism
      • loss of function mutation in a tumor suppressor gene
        • regulate cell growth and repair damage
        • see Cell cycle topic
      • because one functioning tumor suppressor gene copy can produce enough functioning protein to prevent neoplasia, two allele alterations needed for neoplasia
        • two-hit model
        • note many of the inherited cancer disorders have an inherited loss of 1 copy
    • Examples
      • Tumor Suppressor Genes
      • Gene
      • Associated Tumor
      • Chromosome
      • APC
      • Colorectal cancer (associated with FAP)
      • 5
      • p16
      • Melanoma
      • 9
      • WT1
      • Wilms' tumor
      • 11
      • Rb
      • Retinoblastoma and osteosarcoma
      • 13
      • BRCA2
      • Breast cancer
      • 13
      • NF1
      • Neurofibromatosis type 1
      • 17
      • BRCA1
      • Breast and ovarian cancer
      • 17
      • TP53
      • Most human cancers and Li-Fraumeni syndrome
      • 17
      • DPC
      • Pancreatic cancer (stands for deleted in pancreatic cancer)
      • 18
      • DCC
      • Colon cancer (stands for deleted in colon cancer)
      • 18
      • NF2
      • Neurofibromatosis type 2
      • 22
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