Review Question - QID 210733

A 13-year-old boy is brought to his pediatrician for evaluation of leg pain. Specifically, he has been having pain around his right knee that has gotten progressively worse over the last several months. On presentation, he has swelling and tenderness over his right distal femur. Radiographs are obtained and the results are shown in figure A. His family history is significant in that several family members also had this disorder and others had pathology in the eye near birth. The patient is referred for a genetic consult, and a mutation is found on a certain chromosome. The chromosome that is most likely affected also contains a gene that is associated with which of the following pathologies?